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Progeria

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Progeria - Page Text Content

S: PROGERIA

BC: READ ME! written by NIkki Goad

FC: P R O G E R I A written by Nikki Goad

1: Hutchinson Gilford Progeria Syndrome (HGPS), more commonly known as Progeria, is a rare and ultimately fatal genetic disorder. Written by Nikki Goad in class 4B

2: SYMPTOMS | protruding ears are trademark characteristics of sufferers of Progeria. Unfortunately, children with this disease are mentally the same, if not more advanced, than normal children. This means that they have to learn to deal with the way they look, and to deal with the isolation of the other children, who may well be afraid of them. | rotruding ears are trademark characteristics of sufferers of Progeria. Unfortunately, children with this disease are mentally the same, if not more advanced, than normal children. This means that they have to learn to deal with the way they look, and to deal with the isolation of the other children, who may well be afraid of them.

3: Children with Progeria suffer from ailments usually associated with old age. They have cardio, heart, and joint problems. Their skin becomes thin, wrinkled, and spotted. They suffer from hair loss, which in turn shows the prominent scalp veins most tend to have. These children have a short stature due to stunted growth, and a head that is disproportionately large for their face and body. Their facial features are all strangely similar. A beak nose, along with thin lips and | protruding ears are trademark characteristics of sufferers of Progeria. Unfortunately, children with this disease are mentally the same, if not more advanced, than normal children. This means that they have to learn to deal with the way they look, and to deal with the isolation of the other children, who may well be afraid of them.

4: TRANSMISSION What many people need to understand is that HGPS is not a contagious or heredity disease. Meaning that you cant "catch" it and it is very, very rarely "passed down" from one generation to another. It is a genetic disorder. Just like Down Syndrome or Sickle Cell. It is caused from a mutating gene. This mutated gene just happened to cause these children to age rapidly.

6: LIFE EXPECTANCY | Sadly, most children afflicted with this disease have their life cut short, and die in their mid teens. The life of a Progeria child span only an average of thirteen years. Some have been known to die from Progeria related illnesses, as young as seven. The very oldest only make it to their mid-thirties.

7: Children with Progeria often die from illnesses such as stroke, heart disease, and heart failure. All of which are very uncommon for someone so young.

8: TREATMENT

9: To date, there is still no known cure for those with HGPS, and no way to prevent it. The only thing to do is to treat and monitor the symptoms. Children are given a daily aspirin to help lower the risk of heart attack or stroke. They go to physical therapy to help develop and maintain muscle and joint health. A high calorie diet is necessary to help them gain weight. Monthly checkups to the doctor are required to spot and treat problems with the heart.

10: S T A I S T I C S

11: There have been less then 150 cases of Progeria reported since the disease was first described in 1886. This factor may make the statistics seem a little extreme. So, of the few cases that have been evaluated, researchers have discovered the following. Hutchinson Gilford Progeria syndrome affects one in every eight to five million children. Of those children, researchers estimate that 97% of those cases will belong to Caucasians. Finally, it is thought that males are affected slightly more than females, with a 1.5:1 ratio.

12: GENE/CHROMOSOME # | Scientists have recently made some new and possibly life changing discoveries about the causes of HGPS. Scientists did a study and found that 70% of Progeria had a malformation of Chromosome 1. This intern caused a mutation on a gene know as LMNA. The gene LMNA produces a protein called Lamin A. This protein makes up part of the nuclear membrane. This mutation hinders the production of this protein, causing the nucleus to be oddly shaped. Scientists think that this malformation of the nucleus causes the cells to die prematurely, and when your cells die at a faster rate than they are produced, you die.

13: A huge thank you to the following... -Progeria Research Foundation website -UXL Encyclopedia of Diseases and Disorders -Gene Reviews : HGPS -Worldbook P:15 -Mayoclinic.com -Yahoo Images

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Genetic Disorders 4B
  • By: Genetic D.
  • Joined: almost 7 years ago
  • Published Mixbooks: 2
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About This Mixbook

  • Title: Progeria
  • Nikki Goad
  • Tags: None
  • Published: almost 7 years ago

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