1: There are two types of hemophilia: Hemophilia A & Hemophilia B
2: Symptoms of Hemophilia | Bleeding to joints, with associated pain and swelling | Bruising, or spontaneous bleeding | Prolonged bleeding from cuts, tooth extraction & surgery
3: Tests & Diagnosis: Many blood clotting tests are performed if the person tested is the first one in the family to have a bleeding disorder. Once the defect has been identified, other family members will need less tasting to diagnose the disorder.
6: Hemophilia is a sex carried disease. The defective gene that carries this disease is the X chromosome, which determines if the baby is a boy or a girl. | Boys are more likely to get the disease than girls. Because the disease is only carried on the X chromosome, If an infected father passes on the trait, only his daughter can get it, not his son.
7: If the mother is a carrier, she can pass the gene on to both her son and/or daughter. If the father is a carrier, he may only pass it on to his daughters. His sons will not get the default gene from him.
8: Causes: Hemophilia A results from a deficiency (lack) of clotting factor VIII. This disease is cause be a defect in the genes that determine how the body makes blood clotting factors VIII and IX. These genes are located on the X chromosomes, which determine weather a baby is a boy or girl.
9: This disorder is caused by an inherited X-Linked trait, with the defective gene located on the X chromosome. Females have two copies of the X chromosome, so if the factor VIII gene on one chromosome is defective, the gene on the other chromosome can do the job of making enough VIII. Males, however, have only one X chromosome, so if the factor VIII gene on the chromosome is defective, they will have Hemophilia A. Thus, most people with Hemophilia A are male.
11: Standard treatment involves replacing the missing clotting factor. The amount of factor VIII concentrates needed depends on how severe the bleeding is, the site of the bleeding, and the size of the patient. Mild hemophilia may be treated with desmopressin (DDAVP), which helps the body release factor VIII that is stored within the lining of blood vessels.
12: To prevent a bleeding crisis, people with hemophilia and their families can be taught to give factor VIII concentrates at home at the first signs of bleeding. | People with severe forms of the disease may need regular preventative treatment.