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Fibrodysplasia Ossificans Progressiva

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Fibrodysplasia Ossificans Progressiva - Page Text Content

FC: Fibrodysplasia Ossificans Progressiva

1: What is Fibrodysplasia Ossificans Progressiva or 'FOP'? Fibrodysplasia is a genetic disorder in which the patient's muscles slowly ossify into bone. It is a rare genetic disease, and very few people in the population are afflicted.

2: What are FOP's symptoms? Physically, the diseased person may be bent over and have loss of movement. Over time, malnutrition and breathing problems may occur because of the afflicted's inability to use these parts.

3: In addition, any operations, trauma (anything as simple as a fall), and unrelated sicknesses (like the flu) can cause a flare-up of unstoppable bone growth. Usually, persons born with FOP have malformed toes and sometimes short thumbs and other skeletal abnormalities.

4: How do people get FOP? FOP is autosomal dominant, meaning that if you are a carrier, you are also a recipient.

5: Most cases of FOP are from mutations and- excluding the small number of cases that are direct parental transfers and mostly, there is no evident medical history.

6: The Life Expectancy Most patients who have FOP do not live very long, as the bone constricts

7: their bodies, leaving them prisoners in their own bones. The oldest man on records lived to about forty-four years of age. He dedicated his body to science to encourage finding a cure.

8: There is no cure.

9: Surprisingly, any extra bone growth can be removed- however, seeing as any surgery will inflame the muscles, the ossification returns to the same place more rapidly than before.

10: The gene believed to be the cause is the 'ACVR1' gene, which controls the growth of the bones and may be randomly turned on because of a change in the receptor's shape. | The Gene

11: One in Two Million | There is only a one in two million chance to get FOP. | Several hundred cases have reported.

12: Bibliography |

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  • By: Jessinia
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  • Title: Fibrodysplasia Ossificans Progressiva
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  • Published: over 8 years ago