S: The Lonely DNA
FC: Alex Downing | THE LONELY DNA
1: Once there was a double helix of DNA. The two strands were best friends and never wanted to part. They were a complementary pair of nucleotide bases. | Their days were spent swirling about the nucleus until one day all the DNA gathered in chromosome formation.
2: The DNA did not know what was happening. But soon enough they spotted the helicase coming towards them. "Oh no!" cried one strand, "We will be separated for sure." "Don't worry," said the other, "this is all part of the replication process." The helicase approached them and began to separate the long time friends. "What will I do without you," cried the first strand. "You just have to make a new strand," called the second strand as the two friends were completely separated.
4: Ligase | DNA Polymerase | RNA Primer
5: The strand of DNA was stranded out on its own. Without his friend he was very lonely. Then on the horizon the strand of DNA saw an RNA primer, DNA polymerase, and ligase. "Oh goody," thought the lonely strand, "Maybe they will be my friends now." The group of enzymes moved closer to the lonely strand of DNA. "Hello," called out the little strand, "Will you be my friends? I was separated from my complementary strand." The enzymes looked at each other and replied, "We're sorry but we can't be your friends. We are only passing through, but we would love to help you find a new friend so you won't be so lonely." The DNA smiled at the enzymes that offered to help him find a new friend.
6: "How do I find a new friend as good as my old friend?", questioned the DNA strand. "Well it is quite simple," said the DNA Polymerase, "I know exactly what to do. You, RNA primer and ligase, stay with the DNA. I'll be back soon." The polymerase wandered off to the distance. The ligase said, "Don't worry we have helped many lonely DNA strands make new friends." "That's good," said the DNA, "I'll be much happier when I'm not alone anymore. Thank you very much for helping me out." "It is our pleasure. Making new strands of DNA is what we are made to do." "Where did DNA Polymerase go off to?" asked the DNA. "Oh he will be back soon with a herd of nucleotide bases," replied the ligase.
9: On the distance a herd of nucleotide bases was coming over the hill with DNA polymerase in the lead. "Alrighty," shouted the polymerase,"Here they come! I'm going to match up the bases to make your new best friend." "I'll start you off," called the RNA primer." "And I will add the finishing touches," stated the ligase. The bases came charging over the hill and the replication began. The once lonely strand of DNA was now making a new friend.
10: Adenine paired with thymine, cytosine paired with guanine, over and over and over. Finally the new strand was complete, "Hello!" it said gleefully. "Hello! Will you be my friend?" replied the once lonely strand. "Of course I will." The ligase finished up and linked the two strands in friendship. "You should be all set now," said the ligase. "Thank you so much!" called out the double helix of DNA now made of two strands, the best of friends. The ligase, helicase, DNA polymerase, and RNA primer all left the DNA to enjoy the time with its new best friend.
13: Works Cited and Pictures Courtesy Of en.wikipedia.org info.cancerresearchuk.org cs.stedwards.edu worldaroundus.org.uk biochem.umd.edu sciencephoto.com ibhumanbiochemistry.wikispaces.com dna-sequencing-service.com